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KMID : 1149220100180020183
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Korean Journal of Oriental Medical Prescription
2010 Volume.18 No. 2 p.183 ~ p.199
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Effects of FLOS LONICERAE Water Extract On Anti-Rheumatiod Arthritis
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Kim Hee-Soo
Ki Ho-Pil
Lee Joon-Suh
Yun Young-Gab
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Abstract
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Rheumatoid arthritis is characterized by the focal loss of cartilage due to an up-regulation of inflammatory pathways, which produce inflammatory mediators, such as interleukin-1beta(IL-), IL-6, tumour necrosis factor alpha(TNF-), prostaglandin, and nitric oxide(NO). We investigated the anti-arthritic effects of water extract from FLOS LONICERAE(FLWE) in vitro and in vivo. Extract inhibited the production of inflammatory mediators(NO, IL-, TNF-, and prostaglandin ) and the expression of inducible NO synthase(iNOS) and cyclooxygenase-2(COX-2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in a dose-dependent manner. FLWE also inhibited TNF-, IL-, IL-6, and production as well as COX activity in collagen-induced mouse arthritis. Moreover, FLWE significantly suppressed collagen-induced mouse arthritis. These results suggest that FLOS LONICERAE may be useful for therapy against inflammatory immune diseases and rheumatoid arthritis, probably by suppressing the production of inflammatory mediators.
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KEYWORD
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Anti-Rheumatiod, FLOS LONICERAE
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